The DNA methyltransferase DNMT3A plays an important role in establishing the DNA methylation patterns during development and deregulation of DNMT3A is associated with hematological cancers. with the R882H mutation the most frequently occurring DNMT3A missense mutation in acute myeloid leukemia. Here. the authors present the crystal structures of wild-type and R882H DNMT3A in complex w... https://hollandscountryclothinges.shop/product-category/coats/