Sustained activation of JAK/STAT3 signaling pathway is classically described in Multiple Myeloma (MM). One explanation could be the silencing of the JAK/STAT suppressor genes. through the hypermethylation of SHP-1 and SOCS-1. previously demonstrated in MM cell lines or in whole bone marrow aspirates. https://macorners.shop/product-category/leather-bracelet-with-name-beads-gift-box/